Many close relationships break under the impact of a partner's depression. Even if things don't go that far, two people still have to work hard to stay together. Depression can change a partner's behavior so radically that intimacy can be impossible and the underlying trust of a relationship shaken. As my wife and I discovered, one of the first things you need to do is learn all over again how to communicate, how to be with each other. If we hadn't done that, I doubt we could have kept going over the last 25 years.
Source: http://www.mentalhelp.net/poc/view_doc.php?type=doc&id=45311&cn=5
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