There is nothing so lonely and heart wrenching for family members than to have a loved one who suffers from one of the chronic mental illnesses. These are what are known as the psychoses, among which are the Schizophrenias, Bipolar Illnesses and Bipolar illness with psychotic features, among others.
Source: http://www.mentalhelp.net/poc/view_doc.php?type=doc&id=43870&cn=144
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